DICER1 Polyclonal Antibody

DICER1 Polyclonal Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Polyclonal antibody to DICER1

IF

Human

DICER1 antibody; DCR1 antibody; Dicer antibody; Dicer1e antibody; HERNA antibody; K12H4.8-LIKE antibody; MNG1 antibody; RMSE2 antibody; endoribonuclease Dicer antibody

Rabbit IgG

Antigen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human DICER1 (NP_001258211.1).

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

IF 1:50 - 1:200

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.