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Product Name
Desmin antibody
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Description
Desmin Mouse Monoclonal antibody. Positive IHC detected in human heart tissue, human hysteromyoma tissue, human skeletal muscle tissue. Positive WB detected in Human heart. Observed molecular weight by Western-blot: 55 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse; other species not tested.
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Alternative names
DES antibody; desmin antibody
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Isotype
Mouse IgG2a
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Preparation
This antibody was obtained by immunization of Desmin recombinant protein (Accession Number: NM_001927). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:50-1:200
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Validations
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:107239(DES antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human heart using Catalog No:107239(DES antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human heart using Catalog No:107239(DES antibody) at dilution of 1:50 (under 40x lens)
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Background
Desmin is the main intermediate filament protein in skeletal and cardiac muscle cells and is essential for both the structural integrity and the survival of muscle cells. As an abundant muscle-specific protein, desmin has been widely used as a marker of muscle derived tumors. Anti-desmin is also valuable in the differential diagnosis of tumors of uncertain origin.
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References
- Zhou M, Zhao F, Li J. Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with non-parenchymal cells. Journal of virological methods. 195:185-93. 2014.
- Gao P, Meng XF, Su H. Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy. Biochimica et biophysica acta. 1843(11):2448-60. 2014.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"