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Product Name
Human XTP3TPA / DCTPP1 (His Tag) recombinant protein
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Description
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).
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Protein name
dCTP pyrophosphatase 1
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Protein short names
2410015N17RIK; XTP3-TRANSACTIVATED GENE A PROTEIN; XTP3TPA; CDA03; AI854235; XTP3-TRANSACTIVATED PROTEIN A; DEOXYCYTIDINE-TRIPHOSPHATASE 1; RS21C6; DCTPASE 1; RS21-C6; DCTP PYROPHOSPHATASE 1; DCTPP1
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Uniprot ID
Q9H773
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Gene Name
DCTPP1; XTP3TPA; CDA03
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human XTP3TPA(NP_077001.1) (Met1-Thr170) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human XTP3TPA consists of 185 amino acids and predicts a molecular mass of 20.5 KDa. It migrates as an approximately 21 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human XTP3TPA / DCTPP1 Protein (His Tag) SDS-PAGE
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