-
Product Name
Anti-XTP3TPA / DCTPP1 antibody
- Documents
-
Description
Rabbit polyclonal to XTP3TPA / DCTPP1
-
Tested applications
ELISA, WB, IHC-P, IP
-
Species reactivity
Human XTP3TPA / DCTPP1
-
Alternative names
dCTP pyrophosphatase 1 antibody; DCTPP1 antibody; CDA03 antibody; RS21C6 antibody; XTP3TPA antibody; XTP3-transactivated gene A protein antibody; XTP3-transactivated protein A antibody; dCTPase 1 antibody; deoxycytidine-triphosphatase 1 antibody; CDA03 antibody; RS21C6 antibody; XTP3TPA antibody; RS21-C6 antibody; AI854235 antibody; 2410015N17Rik antibody
- Immunogen
-
Isotype
Rabbit IgG
-
Preparation
Produced in rabbits immunized with purified, recombinant Human XTP3TPA / DCTPP1 (rh XTP3TPA / DCTPP1; NP_077001.1; Met1-Thr170). XTP3TPA / DCTPP1 specific IgG was purified by Human XTP3TPA / DCTPP1 affinity chromatography.
-
Clonality
Polyclonal
-
Formulation
0.2 μm filtered solution in PBS
-
Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 2-10 μg/ml
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human XTP3TPA / DCTPP1. The detection limit for Human XTP3TPA / DCTPP1 is < 0.039 ng/well.
IHC-P: 0.01-0.1 μg/ml
IP: 0.5-2 μg/mg of lysate
-
Validations
XTP3TPA / DCTPP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
XTP3TPA / DCTPP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
XTP3TPA / DCTPP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
XTP3TPA / DCTPP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
-
Background
DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. DCTPP1 also hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). DCTPP1 does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. It may protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. DCTPP1 may also protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.
-
References
- Stelzl U. et al., 2005, Cell. 122 (6): 957-68.
- Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
- Moroz OV. et al., 2005, J Mol Biol. 347 (2): 243-55.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"