Human DCUN1D1 / SCCRO (His Tag) recombinant protein

Human DCUN1D1 / SCCRO (His Tag) recombinant protein

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Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

DCN1-like protein 1

DEFECTIVE IN CULLIN NEDDYLATION 1; TESTIS DERIVED TRANSCRIPT 3; DCN1; SQUAMOUS CELL CARCINOMA-RELATED ONCOGENE; DCN1-LIKE PROTEIN 1; DCUN1L1; DCUN1 DOMAIN-CONTAINING PROTEIN 1; RP42 HOMOLOG; DEFECTIVE IN CULLIN NEDDYLATION PROTEIN 1-LIKE PROTEIN 1; DOMAIN CONTAINING 1 (S. CEREVISIAE); RP42; DCNL1; PTES3; DOMAIN CONTAINING 1 (S. CEREVISIAE); TES3; SCRO; SCCRO; DEFECTIVE IN CULLIN NEDDYLATION 1; TESTIS-SPECIFIC PROTEIN 3; DCUN1D1

Q96GG9

DCUN1D1; DCUN1L1; RP42; SCCRO

E. coli

A DNA sequence encoding the human DCUN1D1 (NP_065691.2) (Met1-Val259) was expressed with a polyhistidine tag at the N-terminus.

Human

The recombinant human DCUN1D1 consists of 274 amino acids and predicts a molecular mass of 32 KDa. It migrates as an approximately 28-32 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE