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Product Name
Human CRELD1 (His Tag) recombinant protein
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Description
CRELD1 is a transmembrane glycoprotein. Epidermal growth factor(EGF)Âlike domain exists in CRELD1. EGF-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 contains a 333 amino acid acid (aa) extracellular domain (ECD), two tandem transmembrane segments, and a second ECD of 15 aa. Defects in CRELD1 may cause susceptibility to atrioventricular septal defect type 2 which results in a persistent common atrioventricular canal.
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Protein name
Cysteine-rich with EGF-like domains 1, isoform CRA_b
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Protein short names
AVSD2; CIRRIN; CYSTEINE-RICH WITH EGF-LIKE DOMAIN PROTEIN 1; I11E7 PROTEIN; AI843811; UNQ188/PRO214
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Uniprot ID
Q96HD1
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Gene Name
CRELD1; hCG_2039468
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CRELD1 (NP_001070883.1) (Met1-Glu362) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CRELD1 consists of 344 amino acids and predicts a molecular mass of 37.4 KDa. It migrates as an approximately 51 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human CRELD1 Protein (His Tag) SDS-PAGE
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