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Product Name
Cynomolgus CD53 (aa 107-181, Fc Tag) recombinant protein
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Description
CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.
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Protein name
Tetraspanin
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Protein short names
OX-44; LEUKOCYTE SURFACE ANTIGEN CD53; TETRASPANIN-25; CD53 ANTIGEN; CELL SURFACE GLYCOPROTEIN CD53; CELL SURFACE ANTIGEN; CD53 MOLECULE; AI323659; CD53; ANTIGEN MOX44 IDENTIFIED BY MONOCLONAL ANTIBODY MRC-OX44; CD53 GLYCOPROTEIN; TSPAN-25; MOX44; TRANSMEMBRANE GLYCOPROTEIN; CD53 TETRASPAN ANTIGEN; TSPAN25
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Uniprot ID
G7NW46
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Gene Name
EGM_00928
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus CD53 (G7NW46) (Glu107-Asn181) was expressed with the Fc region of mouse IgG1 at the N-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus CD53 is a disulfide-linked homodimer. The reduced monomer comprises 311 amino acids and has a calculated molecular mass of 34.9 KDa. The apparent molecular mass of it is approximately 44 KDa respectively in SDS-PAGE.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Cynomolgus CD53 Protein (aa 107-181, Fc Tag) SDS-PAGE
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