CTDSP2 antibody

CTDSP2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CTDSP2 Rabbit Polyclonal antibody. Positive WB detected in human kidney tissue, HepG2 cells, K-562 cells. Positive IHC detected in human pancreas cancer. Observed molecular weight by Western-blot: 31 kDa

ELISA, WB, IHC

human; other species not tested.

CTDSP2 antibody; NLI interacting factor 2 antibody; SCP2 antibody; Protein OS 4 antibody; OS4 antibody

Rabbit IgG

This antibody was obtained by immunization of CTDSP2 recombinant protein (Accession Number: NM_005730). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CTDSPs are C-class phosphatases that act on Ser 5 of the Pol II C-terminal domain (CTD) to decrease transcription [PMID:15681389]. CTDSP enzymatic activity is required for REST function, and knockdown of CTDSP induces the neuronal differentiation of mouse embryonic carcinoma P19 cells. CTDSP2 has been shown to enhance TGF-β signaling by the dephosphorylation of SMAD proteins and attenuates androgen receptor-mediated transcription [PMID:16724108]. It negatively regulates RNA polymerase II transcription by controlling the transition from initiation/capping to processive transcript elongation. It was recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells[PMID: 12721286].