CTCF antibody

CTCF antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CTCF Rabbit Polyclonal antibody. Positive IP detected in MCF-7 cells. Positive WB detected in human brain tissue, 4T1 cells, HEK-293T cells, U-937 cells. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 130-140 kDa

ELISA, WB, IHC, IP

Human, Rat; other species not tested.

11 zinc finger protein antibody; CCCTC binding factor antibody; CTCF antibody; CTCFL paralog antibody; Transcriptional repressor CTCF antibody

Rabbit IgG

This antibody was obtained by immunization of CTCF recombinant protein (Accession Number: XM_017022868). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Transcriptional insulators are DNA elements that set boundaries on the actions of enhancer and silencer elements and thereby organize the eukaryotic genome into regulatory domains. All vertebrate insulators appear to use the versatile CTCF protein. CTCF uses various combinations of its 11 zinc fingers to recognize a variety of unrelated DNA sequences. Once bound to DNA, CTCF can function as a transcriptional insulator, repressor, or activator, depending on the context of the binding site [PMID:12787766,15454938]. In vertebrates, this 11 zinc-finger protein is shown to be crucial in processes of epigenetic imprinting, X chromosome inactivation , and associated with various complex human diseases including cancer and diabetes [PMID:23139640].