CRLS1 antibody

CRLS1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CRLS1 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer. Positive WB detected in mouse heart tissue. Observed molecular weight by Western-blot: 50 kDa

ELISA, WB, IHC

human, mouse; other species not tested.

CRLS1 antibody; GCD10 antibody; Protein GCD10 homolog antibody; cardiolipin synthase 1 antibody; C20orf155 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: BC069010). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Cardiolipin (CL) is a mitochondrial specific double negatively charged phospholipid which is intricately involved in regulating bioenergetic efficiency. In eukaryotes, CL is synthesized by cardiolipin synthase (CRLS1 or CLS1) which catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form CL and glycerol. Recently it has been reported that transgenic expression of CRLS1 accelerates cardiolipin remodeling, improves mitochondrial function, modulates mitochondrial signaling, and attenuates mitochondrial dysfunction during diabetes, thereby identifying CRLS1 as a novel therapeutic target to attenuate mitochondrial dysfunction in diabetic myocardium.