CREST antibody

Cat.#: 107176

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Product Information

  • Product Name
    CREST antibody
  • Documents
  • Description
    CREST Mouse Monoclonal antibody. Positive WB detected in MCF-7 cells. Observed molecular weight by Western-blot: 55 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    CREST antibody; KIAA0693 antibody; LP2261 antibody; SS18 like protein 1 antibody; SS18L1 antibody; SYT homolog 1 antibody
  • Immunogen
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was obtained by immunization of CREST recombinant protein (Accession Number: NM_015558). Purification method: Protein G purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    MCF-7 cells were subjected to SDS PAGE followed by western blot with Catalog No:107176(CREST Antibody) at dilution of 1:500

    MCF-7 cells were subjected to SDS PAGE followed by western blot with Catalog No:107176(CREST Antibody) at dilution of 1:500

  • Background
    SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons. It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain. It helps regulate neuronal morphogenesis in calcuim-dependent manner. The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation. It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"