Cart 2

CREB3L2 antibody

Cat.#: 109548

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    CREB3L2 antibody
  • Documents
  • Description
    CREB3L2 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, mouse liver tissue, mouse testis tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 60-70 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    BBF2H7 antibody; CREB3L2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CREB3L2 recombinant protein (Accession Number: NM_001253775). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IF: 1:20-1:200

  • Validations

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:109548(CREB3L2 Antibody) at dilution of 1:600

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:109548(CREB3L2 Antibody) at dilution of 1:600

    Immunofluorescent analysis of (-20oc Ethanol) fixed HepG2 cells using Catalog No:109548(CREB3L2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of (-20oc Ethanol) fixed HepG2 cells using Catalog No:109548(CREB3L2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2), also named BBF2H7, is a transcriptional activator which is activated during endoplasmic reticulum (ER) stress late phase. It has 3 isoforms produced by alternative splicing. CREB3L2 exerts protective effect in neurons by regulation of unfolded protein response (UPR)-dependent gene transcriptions. N-terminal cytoplamic domain of CREB3L2 is cleaved under ER stress and then translocates to the nucleus. Catalog#14514-1-AP is a rabbit polyclonal antibody raised against N-terminal (1-247aa) of human CREB3L2.
  • References
    • Ishikura-Kinoshita S, Saeki H, Tsuji-Naito K. BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis. The Journal of investigative dermatology. 132(8):2010-8. 2012.
    • Liu C, Zhang X, Huang F. APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. The Journal of biological chemistry. 287(35):29373-83. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"