COPS2/TRIP15 antibody

COPS2/TRIP15 antibody

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• Material Safety Data Sheets (MSDS)

COPS2/TRIP15 Rabbit Polyclonal antibody. Positive IP detected in NIH/3T3 cells. Positive WB detected in HeLa cells, human brain tissue, mouse brain tissue, mouse skeletal muscle tissue, NIH/3T3 cells. Positive IHC detected in human ovary tumor tissue. Positive IF detected in HeLa cells. Observed molecular weight by Western-blot: 52 kDa

ELISA, IHC, IF, IP, WB

Human, Mouse; other species not tested.

ALIEN antibody; Alien homolog antibody; COPS 2 antibody; COPS2 antibody; CSN2 antibody; SGN2 antibody; Signalosome subunit 2 antibody; TR interacting protein 15 antibody; TRIP 15 antibody; TRIP15 antibody

Rabbit IgG

This antibody was obtained by immunization of COPS2/TRIP15 recombinant protein (Accession Number: NM_004236). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. (refer to UniProt) Catalog#10969-2-AP is a rabbit polyclonal antibody raised against the full-length of human COPS2. The MW of this protein is 52 kDa, and this antibody specially recognises the 52 kDa protein.

• Rao F, Xu J, Khan AB. Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Proceedings of the National Academy of Sciences of the United States of America. 111(45):16005-10. 2014.