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Product Name
Coproporphyrinogen oxidase antibody
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Description
Coproporphyrinogen oxidase Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in K-562 cells, HepG2 cells, human liver tissue. Positive IHC detected in human liver tissue, human testis tissue. Observed molecular weight by Western-blot: 35 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Coprogen oxidase antibody; Coproporphyrinogen oxidase antibody; Coproporphyrinogenase antibody; COX antibody; CPO antibody; CPOX antibody; CPX antibody; HCP antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Coproporphyrinogen oxidase recombinant protein (Accession Number: NM_000097). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:500-1:5000
IHC: 1:20-1:200
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Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:109461(CPOX antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human liver using Catalog No:109461(CPOX antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:109461(CPOX antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-CPOX (IP:Catalog No:109461, 4ug; Detection:Catalog No:109461 1:1000) with HepG2 cells lysate 1800ug.
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Background
CPOX(Coproporphyrinogen-III oxidase, mitochondrial) is also named as CPO and CPX. Human CPO is a 76 kDa protein that is active as a homodimer in the mitochondrial intermembrane pace(PMID:16159891).Mutations in human CPO gene predict the clinical outcome of the disease, with either hepatic hereditary coproporphyria or hematological manifestations of erythropoietic harderoporphyria.CPOX has a transit peptide of 110 aa and the chain contains 344 aa.
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