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Product Name
Mouse Contactin 1/CNTN1 (His Tag) recombinant protein
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Description
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
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Protein name
Contactin-1
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Protein short names
GP135; F3; CNTN; MYPCN; AW495098; CONTACTIN 1; F3CAM; CNTN1
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Uniprot ID
P12960
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Gene Name
Cntn1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse CNTN1 (NP_031753.1) (Met1-Leu1000) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse CNTN1 comprises 991 amino acids and has a predicted molecular mass of 110.5 kDa. The apparent molecular mass of the protein is approximately 110-120 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse Contactin 1 / CNTN1 Protein (His Tag) SDS-PAGE
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