CNTN1 antibody

CNTN1 antibody

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• Material Safety Data Sheets (MSDS)

CNTN1 Rabbit Polyclonal antibody. Positive WB detected in rat brain tissue. Positive IP detected in rat brain tissue. Observed molecular weight by Western-blot: 135 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

CNTN1 antibody; contactin 1 antibody; Glycoprotein gp135 antibody; GP135 antibody; Neural cell surface protein F3 antibody

Rabbit IgG

This antibody was obtained by immunization of CNTN1 recombinant protein (Accession Number: XM_017018825). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Contactin-1 (CNTN1), also known as Glycoprotein gp135 or Neural cell surface protein F3, is a neuronal cell adhesion molecule of the immunoglobulin superfamily (PMID: 3049624). It consists of six Ig domains, four fibronectin-like motifs, and a glycosylphosphatidylinositol (GPI)-moiety. Expressed by the central and peripheral neurons, CNTN1 contributes to the formation and function of neuronal connections. It plays a role in axon extension and formation of septate-like junctions between axons and myelinating glial cells (PMID: 23724143). In addition, acting as a ligand for Notch, CNTN1 initiates a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination (PMID: 14567914).

• Poitelon Y, Bogni S, Matafora V. Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination. Nature communications. 6:8303. 2015.