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Product Name
CMTM8 antibody
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Description
CMTM8 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human pancreas cancer tissue, human pancreas tissue. Positive IP detected in mouse liver tissue. Positive WB detected in mouse liver tissue, mouse pancreas tissue. Observed molecular weight by Western-blot: 25-28 kDa
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Tested applications
ELISA, IHC, IP, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CKLFSF8 antibody; CKLFSF8 V2 antibody; CMTM8 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CMTM8 recombinant protein (Accession Number: NM_178868). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:1000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:109416(CMTM8 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human liver using Catalog No:109416(CMTM8 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:109416(CMTM8 antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-CMTM8 (IP:Catalog No:109416, 4ug; Detection:Catalog No:109416 1:300) with mouse liver tissue lysate 6800ug.
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Background
CMTM8, also known as CKLFSF8, is a member of the chemokine-like factor superfamily (CKLFSF). Proteins of this family share similarity with both the chemokine and the transmembrane 4 superfamilies. CMTM8 is an attenuator of EGF-induced signaling (PMID: 16263120). Overexpression of CMTM8 accelerates ligand-induced clearance of EGFR from the cell surface and induces apoptosis via caspase-dependent and -independent pathways (PMID: 17149703). An alternative splice form of CMTM8, CMTM8-v2, arises from a deletion of exon 2. CMTM8-v2 maintains the ability to induce apoptosis (PMID: 17681841).
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References
- Gao D, Hu H, Wang Y. CMTM8 inhibits the carcinogenesis and progression of bladder cancer. Oncology reports. 34(6):2853-63. 2015.
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