Cart 2

CLASP2 antibody

Cat.#: 109334

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    CLASP2 antibody
  • Documents
  • Description
    CLASP2 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, HEK-293 cells. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 140-160 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    CLASP2 antibody; CLIP assOCiating protein 2 antibody; hOrbit2 antibody; KIAA0627 antibody; Protein Orbit homolog 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CLASP2 recombinant protein (Accession Number: BC029035). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:50-1:500

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:109334(CLASP2 antibody) at dilution of 1:500

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:109334(CLASP2 antibody) at dilution of 1:500

    Immunofluorescent analysis of HepG2 cells using Catalog No:109334(CLASP2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of HepG2 cells using Catalog No:109334(CLASP2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    CLASP2 (CLIP-associating protein 2) is a brain specific protein belongs to CLASP family. CLASP1 and CLASP2 regulate microtubule plus-end dynamics in brine cortex. CLASP2 is required for the orientation of stabilized microtubules toward the leading edge, It may act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms. Phosphorylation of CLASP2 by GSK3B may negatively regulate binding to microtubule lattices in lamella.
  • References
    • Matsumoto T, Nagase Y, Hirose J. Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase B-mediated microtubule stabilization. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 28(5):1191-202. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"