CHD1 antibody

CHD1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CHD1 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive WB detected in HeLa cells, A431 cells, human brain tissue, Jurkat cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 200 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

ATP dependent helicase CHD1 antibody; CHD 1 antibody; CHD1 antibody; DKFZp686E2337 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_001270). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CHD1 belongs to the SNF2/RAD54 helicase family. CHD1 is an aTP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. CHD1 regulates polymerase II transcription. It is required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. CHD1 regulates negatively DNA replication. It is required to maintain a specific chromatin configuration across the genome. It is associated with histone deacetylase (HDAC) activity. CHD1 is required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. It functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. It is required for maintaining open chromatin and pluripotency in embryonic stem cells. The antibody is specific to CHD1.

• Piatti P, Lim CY, Nat R. Embryonic stem cell differentiation requires full length Chd1. Scientific reports. 5:8007. 2015.
• Wille A, Maurer V, Piatti P. Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors. Frontiers in behavioral neuroscience. 9:313. 2015.