Human TRIP10/Protein Felic (His Tag)

Human TRIP10/Protein Felic (His Tag)

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Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Cdc42-interacting protein 4

AI646975; HSTP; CDC42-INTERACTING PROTEIN 4; THYROID HORMONE RECEPTOR INTERACTOR 10; STP; THYROID RECEPTOR INTERACTING PROTEIN 10; THYROID RECEPTOR-INTERACTING PROTEIN 10; TRIP-10; PROTEIN FELIC; SALT TOLERATOR; STOT; TRIP10; SALT TOLERANT PROTEIN; CIP4; TR-INTERACTING PROTEIN 10; CDC42 INTERACTING PROTEIN-4

Q15642

TRIP10; CIP4; STOT; STP

Baculovirus-Insect Cells

A DNA sequence encoding the human TRIP10 Isoform 2 (NP_004231.1) (Met1-Asn545) was expressed with a C-terminal polyhistidine tag.

Human

The secreted recombinant human TRIP10 consists of 556 amino acids and predicts a molecular mass of 64 KDa. The apparent molecular mass of the protein is approximately 84.2 KDa in SDS-PAGE under reducing conditions.

> 85 % as determined by SDS-PAGE