Anti-Cip4 Rabbit antibody
Cip4 Rabbit monoclonal antibody
Human, Mouse, Rat
STP; CIP4; HSTP; STOT; TRIP-10 antibody
Antigen: A synthetic peptide of human Cip4
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of Cip4 in 3T3 cell lysates using Cip4 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:80kDa.
Swiss-Prot Acc.Q15642.Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling . Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
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