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  • Anti-Cip4 Rabbit antibody

Anti-Cip4 Rabbit antibody

Cat.#: 168927

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Cip4 Rabbit antibody
  • Documents
  • Description
    Cip4 Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    STP; CIP4; HSTP; STOT; TRIP-10 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Cip4
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:1000-1:5000

    1:20-1:100

  • Validations

    Western blot detection of Cip4 in 3T3 cell lysates using Cip4 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:80kDa.

    Western blot detection of Cip4 in 3T3 cell lysates using Cip4 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:80kDa.

  • Background
    Swiss-Prot Acc.Q15642.Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling . Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"