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Product Name
Cynomolgus CD86/B7-2 (His Tag) recombinant protein
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Description
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
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Protein name
CD86 protein
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Protein short names
LAB72; MB7-2; B7.2; CD86; LY-58; MB7; LY58; B70; CD28LG2; TS/A-2; CD28L2; B7-2; CLS1; ETC-1; MGC34413; B7
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Uniprot ID
Q9BDM4
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus CD86 (Q9BDM4) (Met1-His239) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus CD86 comprises 231 amino acids and has a calculated molecular mass of 26.7 KDa. The apparent molecular mass of it is approximately 54-66 KDa respectively in SDS-PAGE.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Cynomolgus CD86 / B7-2 Protein (His Tag) SDS-PAGE
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