CD41/Integrin alpha 2b antibody

CD41/Integrin alpha 2b antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CD41/Integrin alpha 2b Rabbit Polyclonal antibody. Positive WB detected in human blood tissue. Positive IP detected in human plasma tissue. Positive IHC detected in human spleen tissue. Observed molecular weight by Western-blot: 125 kDa

ELISA, IHC, IP, WB

Human; other species not tested.

CD41 antibody; CD41B antibody; GP2B antibody; GPalpha IIb antibody; GPIIb antibody; GTA antibody; HPA3 antibody; Integrin alpha IIb antibody; ITGA2B antibody; ITGAB antibody

Rabbit IgG

This antibody was obtained by immunization of CD41/Integrin alpha 2b recombinant protein (Accession Number: NM_000419). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen.