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CC2D1B antibody

Cat.#: 108952

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Special Price 239.0 USD

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Product Information

  • Product Name
    CC2D1B antibody
  • Documents
  • Description
    CC2D1B Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, human placenta tissue, mouse kidney tissue, SH-SY5Y cells. Observed molecular weight by Western-blot: 120 kDa
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CC2D1B antibody; Freud-2 antibody; KIAA1836 antibody; LGD1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CC2D1B recombinant protein (Accession Number: BC007912). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IP: 1:200-1:2000

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:108952(CC2D1B antibody) at dilution of 1:500

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:108952(CC2D1B antibody) at dilution of 1:500

    IP Result of anti-CC2D1B (IP:Catalog No:108952, 4ug; Detection:Catalog No:108952 1:500) with mouse brain tissue lysate 2560ug.

    IP Result of anti-CC2D1B (IP:Catalog No:108952, 4ug; Detection:Catalog No:108952 1:500) with mouse brain tissue lysate 2560ug.

  • Background
    CC2D1B/Freud2 and CC2D1A/Freud1 are two homologs belonging to the evolutionary conserved Lgd protein family that is involved in endosomal trafficking. CC2D1B has been identified as the novel repressor of postsynaptic 5-HT1A expression. The predicted molecular weight of CC2D1B is 89 kDa, but the observed molecular weight is around 120 kDa, which may be caused by post-translational modification. This antibody is specific to CC2D1B, which has been confirmed by siRNA test. (19423080 , 2672064)
  • References
    • Drusenheimer N, Migdal B, Jäckel S. The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. PLoS genetics. 11(12):e1005749. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"