Caspase 6/p18/p11 antibody

Caspase 6/p18/p11 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Caspase 6/p18/p11 Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue, human lung cancer tissue, human skin tissue. Positive WB detected in Jurkat cells, HeLa cells, mouse brain tissue. Observed molecular weight by Western-blot: 33-35 kDa

ELISA, WB, IHC

Human, Mouse, Rat; other species not tested.

Apoptotic protease Mch 2 antibody; CASP 6 antibody; CASP6 antibody; Caspase 6 antibody; Caspase 6/p18/p11 antibody; Caspase6 antibody; MCH2 antibody

Rabbit IgG

This antibody was obtained by immunization of Caspase 6/p18/p11 recombinant protein (Accession Number: NM_001226). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Caspase-6 belongs to caspase family of cysteinyl-aspartate specific proteases.Precursor of CASP6 produces two subunits, large (18kDa) and small (16kDa) that dimerize. It cleaves poly(ADP-ribose) polymerase, as well as lamins and is involved in the activation cascade of caspases responsible for apoptosis execution. Researches showed that CASP6 could be an early instigator of neuronal dysfunction and regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry. IRAK3 is an important target for CASP6. It can reveal five bands of 28, 32, 36, 49, and 64 kDa in human neurons and fetal brain in western blot, the 32 and 28 kDa bands represent procaspase-6 and pro-arm caspase-6. Procaspase-6 is more abundant than pro-arm caspase-6 in adult tissue, whereas pro-arm caspase-6 is more abundant than pro-caspase-6 in fetal brain and cultured neurons. The higher molecular mass bands at 49 and 64 kDa likely represent dimers of p28 and p32.(PMID:10438520). In rat testis, it can be detected two bands of 34 kDa and 12 kDa or 14 kDa(PMID:12538628).

• Liao H, Bao X, Zhu J. O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway. Chemico-biological interactions. 242:91-8. 2015.