CAPZA1 antibody

CAPZA1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CAPZA1 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue, human stomach cancer tissue. Positive WB detected in human heart tissue, mouse brain tissue, mouse heart tissue. Observed molecular weight by Western-blot: 34-40 kDa

ELISA, WB, IHC

Human, Mouse; other species not tested.

CAPPA1 antibody; CAPZ antibody; CapZ alpha 1 antibody; CAPZA1 antibody; CAZ1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_006135). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CAPZA1 belongs to the F-actin-capping protein alpha subunit family. F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. The potential for CAPZ is a therapeutic target in the management of heart failure. Future research is required to determine the mechanisms by which changes in CAPZ impact myocardial function and intracellular signalling, and to develop feasible strategies that can manipulate CAPZ in the intact heart. (PMID: 15614336 ) This antibody is specific to CAPZA1.