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  • Human VE-Cadherin/CD144 (His & Fc Tag) recombinant protein

Human VE-Cadherin/CD144 (His & Fc Tag) recombinant protein

Cat.#: 502906

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Product Information

  • Product Name
    Human VE-Cadherin/CD144 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
  • Protein name
    Cadherin-5
  • Protein short names
    CD144; VECAD; 7B4; AA408225; VE-CAD; FLJ17376; CDH5; VE-CADHERIN; VECD; VEC
  • Uniprot ID
    P33151
  • Gene Name
    CDH5
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human CDH5 (NP_001786.2) (Met 1-Gln 593) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CDH5/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 815 amino acids after removal of the signal peptide and has a predicted molecular mass of 92 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CDH5/Fc monomer is approximately 120 kDa due to glycosylation.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    Measured by the ability of the immobilized protein to support the adhesion of MCF-7 human breast adenocarcinoma cells. When 5 x 10E4 cells/well are added to Recombinant Human Cadherin-5 coated plates (0.8 μg/mL with 100 μL/well), approximately >50% will adhere after 1 hour at 37℃.
  • Validations

    Human VE-Cadherin / CD144 / CDH5 Protein (His & Fc Tag) SDS-PAGE

    Human VE-Cadherin / CD144 / CDH5 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"