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Product Name
Mouse VE-Cadherin/CD144 (His Tag) recombinant protein
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Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
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Protein name
Cadherin-5
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Protein short names
VECAD; 7B4; CD144; AA408225; VE-CAD; FLJ17376; VECD; VEC; VE-CADHERIN; CDH5
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Uniprot ID
P55284
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Gene Name
Cdh5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse CDH5 (NP_033998.2) extracellular domain (Met 1-Ala 592) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse CDH5 comprises 559 (mature form) or 580 (pro form) amino acids and has a predicted molecular mass of 63.5 (or 66) kDa. As a result of glycosylation, the apparent molecular mass of rmCDH5 is approximately 75-85 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse VE-Cadherin / CD144 / CDH5 Protein (His Tag) SDS-PAGE
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