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Product Name
Human DC-SIGNR/CD299 recombinant protein
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Description
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.
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Protein name
C-type lectin domain family 4 member M
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Protein short names
HP10347; CD299; DC-SIGNR; MGC47866; MGC129964; DCSIGNR; CLEC4M; L-SIGN; LSIGN; DC-SIGN2; CD209L
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Uniprot ID
Q9H2X3
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Gene Name
CLEC4M; CD209L; CD209L1; CD299
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CLEC4M (NP_055072.3) (Ser78-Glu399) was expressed.
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Protein Species
Human
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Molecular weight
The recombinant human CLEC4M consists 322 amino acids and predicts a molecular mass of 37 kDa.
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Purity
> (50.1+31.8) % as determined by SDS-PAGE.
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Validations
Human DC-SIGNR / CD299 Protein ()
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