BORIS antibody

BORIS antibody

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BORIS Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells, HeLa cells, mouse testis tissue, rat testis tissue. Positive IF detected in SH-SY5Y cells, HeLa cells. Positive IHC detected in human ovary tumor tissue. Observed molecular weight by Western-blot: 75 kDa

ELISA, IHC, IF, WB

Human, Mouse, Rat; other species not tested.

BORIS antibody; Cancer/testis antigen 27 antibody; CCCTC binding factor antibody; CT27 antibody; CTCF like protein antibody; CTCF paralog antibody; CTCF T antibody; CTCFL antibody; dJ579F20.2 antibody; Zinc finger protein CTCF T antibody

Rabbit IgG

This antibody was obtained by immunization of BORIS recombinant protein (Accession Number: NM_001269040). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CTCFL, also named BORIS (for brother of the regulator of imprinted sites) is a paralogue of the 11 zinc-finger transcription factor, CTCF. It is predominantly expressed in spermatocytes in the testis, also can be found in tumors and cancer cell lines. It mainly participates in insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. It has a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. Present polyclonal anti-CFCFL antibody(11074-2-AP) is produced by immunizing animals with part of C-terminal chain of CTCFL and detect a 75-kDa band and a 55-kDa band.