BNIP3 Polyclonal Antibody

Cat.#: 162403

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Product Information

  • Product Name
    BNIP3 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to BNIP3
  • Tested applications
    IF
  • Species reactivity
    Human
  • Alternative names
    BNIP3 antibody; NIP3 antibody; BCL2 interacting protein 3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human BNIP3 (NP_004043.3).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IF 1:50 - 1:200
  • Validations

    Immunofluorescence - BNIP3 Polyclonal Antibody

    Immunofluorescence - BNIP3 Polyclonal Antibody

    Immunofluorescence analysis of U2OS cells using BNIP3 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"