BLMH antibody

BLMH antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

BLMH Rabbit Polyclonal antibody. Positive WB detected in human colon tissue, mouse pancreas tissue, mouse spleen tissue. Positive IP detected in mouse skin tissue. Positive IF detected in Hela cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 50 kDa

ELISA, WB, IHC, IF, IP

Human,Mouse,Rat; other species not tested.

bleomycin hydrolase antibody; BLM hydrolase antibody; BLMH antibody; BMH antibody

Rabbit IgG

This antibody was obtained by immunization of BLMH recombinant protein (Accession Number: NM_000386). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

BLMH(Bleomycin hydrolase) is also named as BH, BMH and belongs to the peptidase C1 family. The gene is expressed in many human tissues with elevated expression levels found in testis, skeletal muscle, and pancreas, and low levels of expression in colon and peripheral blood leukocytes(PMID:8639621). The protein catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. BH-immunoreactivity is essentially located in the cytoplasm and at the outer membrane of the rough endoplasmic reticulum of epithelial cells of the kidney, as well as in that of hepatocytes of the liver(PMID:17158865).

• Solovjeva L, Firsanov D, Vasilishina A. DNA double-strand break repair is impaired in presenescent Syrian hamster fibroblasts. BMC molecular biology. 16(1):18. 2015.