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Product Name
BCL10 antibody
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Description
BCL10 Rabbit Polyclonal antibody. Positive WB detected in mouse ovary tissue, human ovary cancer. Positive IHC detected in human lung cancer. Observed molecular weight by Western-blot: 32kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
human, mouse; other species not tested.
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Alternative names
BCL10 antibody; Cellular homolog of vCARMEN antibody; CLAP antibody; CARMEN antibody; CARD like apoptotic protein antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of BCL10 recombinant protein (Accession Number: NM_003921). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse ovary tissue were subjected to SDS PAGE followed by western blot with Catalog No:108387(BCL10 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:108387(BCL10 antibody) at dilution of 1:50 (under 40x lens)
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Background
The gene encoding BCL10 was identified by its recurrent translocation t(1;14)(p22;q32) in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. BCL10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activa
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References
- Liu Y, Dong W, Chen L. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. The Journal of biological chemistry. 279(36):37436-44. 2004.
- Dong W, Liu Y, Peng J. The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. The Journal of biological chemistry. 281(36):26029-40. 2006.
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