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Product Name
Human Survivin/BIRC5/API4 recombinant protein
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Description
BIRC5, also known as Survivin and EPR-1, is a member of the IAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Survivin acts as an important regulator of the localization of this complex. It may counteract a default induction of apoptosis in G2/M phase.
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Protein name
Baculoviral IAP repeat-containing protein 5
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Protein short names
BACULOVIRAL IAP REPEAT CONTAINING 5; BACULOVIRAL IAP REPEAT-CONTAINING 5; AAC-11; EPR-1; SURVIVIN VARIANT 3 ALPHA; BIRC5; APOPTOSIS INHIBITOR SURVIVIN; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5; SURVIVIN40; TIAP; RP23-268N22.2; API4; APOPTOSIS INHIBITOR 4; SURVIVIN
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Uniprot ID
O15392
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Gene Name
BIRC5
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human BIRC5 (NP_001159.2) (Met1-Asp142) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human BIRC5 consists of 144 amino acids and predicts a molecular mass of 16.5 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human Survivin / BIRC5 / API4 Protein SDS-PAGE
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