Rhesus TNFRSF17/BCMA?CD269? (Fc Tag) recombinant protein

Rhesus TNFRSF17/BCMA?CD269? (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

B-cell maturation protein

TNFRSF13A; TNFRSF17; TNFRSF13; BCM; BCMA; CD269

F7FFA0

TNFRSF17; EGK_12514

Human Cells

A DNA sequence encoding the rhesus TNFRSF17 (XP_001106892.1) (Met1-Ala53) was expressed with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus TNFRSF17 comprises 294 amino acids and has a calculated molecular mass of 33 KDa.

> 95 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized human BAFF (Cat:503353) at 10 μg/ml (100 μl/well) can bind Rhesus TNFRSF17-Fc, The EC₅₀ of Rhesus TNFRSF17-Fc is 0.03-0.07 μg/mL.