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Product Name
Mouse CD79A / Ig-alpha (Fc Tag) recombinant protein
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Description
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
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Protein name
B-cell antigen receptor complex-associated protein alpha chain
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Protein short names
MB-1 MEMBRANE GLYCOPROTEIN; IG-ALPHA; MEMBRANE-BOUND IMMUNOGLOBULIN-ASSOCIATED PROTEIN; IGALPHA; MEMBRANE-BOUND IMMUNOGLOBULIN-ASSOCIATED PROTEIN; IMMUNOGLOBULIN-ASSOCIATED ALPHA; IG ALPHA; LY54; SURFACE IGM-ASSOCIATED PROTEIN; IGA; IGALPHA; CD79A; IG-ALPHA; CD79A; MB-1; IGA; CD79A ANTIGEN (IMMUNOGLOBULIN-ASSOCIATED ALPHA); LY-54; CD79A MOLECULE; B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN; IG-ALPHA; MEMBRANE GLYCOPROTEIN; IMMUNOGLOBULIN-ASSOCIATED ALPHA
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Uniprot ID
P11911
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Gene Name
Cd79a; Iga; Mb-1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Cd79a (NP_031681.2) (Met1-Arg137) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Cd79a consists 347 amino acids and predicts a molecular mass of 39 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Cd79a protein SDS-PAGE
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