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Product Name
Antithrombin III antibody
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Description
Antithrombin III Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in human blood tissue. Observed molecular weight by Western-blot: 53 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Antithrombin antibody; Antithrombin III antibody; AT3 antibody; ATIII antibody; HEPARIN COFACTOR I antibody; Serpin C1 antibody; SERPINC1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Antithrombin III recombinant protein (Accession Number: BC022309). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IF: 1:50-1:500
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Validations
human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:108107(SERPINC1 antibody) at dilution of 1:300
Immunofluorescent analysis of (-20oc Ethanol) fixed HepG2 cells using Catalog No:108107(SERPINC1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
SERPINC1, also named Antithrombin III or Antithrombin, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
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