Anti-YWHAE antibody

Anti-YWHAE antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human YWHAE

WB, ELISA, ICC/IF, IF, IP

Human 14-3-3 epsilon/YWHAE

KCIP-1 antibody; MDS antibody; HEL2 antibody; MDCR antibody; 14-3-3E antibody; AU019196 antibody; KCIP-1 antibody; 14-3-3 epsilon antibody; 14-3-3 epsilon antibody; 14-3-3E antibody; AU019196 antibody; FLJ45465 antibody; FLJ53559 antibody; MDCR antibody; MDS antibody; RP23-78H4.1 antibody; YWHAE antibody; Ywhae antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human 14-3-3 epsilon/YWHAE . 14-3-3 epsilon/YWHAE specific IgG was purified by Human 14-3-3 epsilon/YWHAE affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.