Anti-VNN1/Vanin-1 antibody

Anti-VNN1/Vanin-1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to VNN1/Vanin-1

ELISA, IHC-P

Mouse VNN1 / Vanin-1

HDLCQ8 antibody; Tiff66 antibody; V-1 antibody; HDLCQ8 antibody; MGC116930 antibody; MGC116931 antibody; MGC116932 antibody; MGC116933 antibody; pantetheinase antibody; pantetheinase antibody; pantetheine hydrolase antibody; pantetheine hydrolase antibody; Tiff66 antibody; V-1 antibody; vanin-1 antibody; vanin-1 antibody; vannin 1 antibody; vascular non-inflammatory molecule 1 antibody; vascular non-inflammatory molecule 1 antibody; Vnn1 antibody; VNN1 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse VNN1 / Vanin-1 (rM VNN1 / Vanin-1; Q9Z0K8; Met1-Ser487). VNN1 / Vanin-1 specific IgG was purified by Mouse VNN1 / Vanin-1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

• Aurrand-Lions M, et al. (1996) Vanin-1, a Novel GPI-Linked Perivascular Molecule Involved in Thymus Homing. Immunity. 5 (5): 391-405.
• Grimmond S, et al. (2000) Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. Hum Mol Genet. 9 (10): 1553-60.
• Meghari S, et al. (2007) Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. Eur J Immunol. 37 (1): 24-32.