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Product Name
Anti-TTF1 Rabbit antibody
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Description
TTF1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
BCH; BHC; NK-2; TEBP; TTF1; NKX2A; NMTC1; T/EBP; TITF1; TTF-1; NKX2.1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human TTF1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/50
ICC/IF: 1/20-1/50
FC: 1/20
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Validations
Western blot detection of TTF1 in K562,CHO-K1,Hela cell lysates using TTF1 Rabbit pAb(1:1000 diluted).Predicted band size:39KDa.Observed band size:39KDa.
Immunohistochemistry of TTF1 in paraffin-embedded Human lung cancer tissue using TTF1 Rabbit pAb at dilution 1/50
Western blot detection of TTF1 in Fetal lung lysates using TTF1 Rabbit pAb(1:1000 diluted).Predicted band size:39KDa.Observed band size:39KDa.
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Background
Swiss-Prot Acc.P43699.Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"