Anti-TBLR1/TBL1XR1 (4F3) Mouse antibody

Anti-TBLR1/TBL1XR1 (4F3) Mouse antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TBLR1/TBL1XR1 (4F3) Mouse monoclonal antibody

WB, IHC-P, ICC/IF

Human, Mouse

C21;DC42;F box like/WD repeat containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1XR1;FLJ12894;IRA1;Nuclear receptor corepressor/HDAC3 complex subunit;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1 related protein 1;TBL1- antibody

Mouse IgG1

Antigen: Purified recombinant human TBLR1 protein fragments expressed in E.coli.

Monoclonal

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4 150 mM NaCl) with 0.02% sodium azide 50% glycerol

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.Q9BZK7.This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.