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  • Anti-SIRP alpha Rabbit antibody

Anti-SIRP alpha Rabbit antibody

Cat.#: 169037

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-SIRP alpha Rabbit antibody
  • Documents
  • Description
    SIRP alpha Rabbit monoclonal antibody
  • Tested applications
    WB, FC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human SIRP alpha
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:1000

    1:20

  • Validations

    Western blot detection of SIRP alpha in Rat Brain lysates using SIRP alpha Rabbit mAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:85kDa.

    Western blot detection of SIRP alpha in Rat Brain lysates using SIRP alpha Rabbit mAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:85kDa.

  • Background
    Swiss-Prot Acc.P78324.Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function . Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"