Anti-SIRP alpha Rabbit antibody

Cat.#: 167575

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Product Information

  • Product Name
    Anti-SIRP alpha Rabbit antibody
  • Documents
  • Description
    SIRP alpha Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human SIRP alpha
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    IHC: 1/50

    ICC/IF: 1/50

    FC: 1/50

  • Validations

    Western blot detection of SIRP alpha in A549,MCF-7,293T cell lysates using SIRP alpha Rabbit mAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:85kDa.

    Western blot detection of SIRP alpha in A549,MCF-7,293T cell lysates using SIRP alpha Rabbit mAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:85kDa.

  • Background
    The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"