Anti-SIAE antibody

Anti-SIAE antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse Monoclonal to Human SIAE

IHC-P

Human sialate O-acetylesterase

AIS6 antibody; clone 165 antibody; CSEC antibody; CSE-C antibody; cytosolic sialic acid 9-O-acetylesterase homolog antibody; H-Lse antibody; LSE antibody; LSE antibody; MGC87009 antibody; sialate O-acetylesterase antibody; sialate O-acetylesterase antibody; sialic acid-specific 9-O-acetylesterase antibody; sialic acid-specific acetylesterase II antibody; yolk sac gene 2 antibody; yolk sac protein 2 antibody; YSG2 antibody; Ysg2 antibody; LSE antibody; AIS6 antibody; CSEC antibody; YSG2 antibody; CSE-C antibody; LSE antibody; Ysg2 antibody

Rabbit IgG

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human sialate O-acetylesterase . The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Sialate O-acetylesterase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. It is widely expressed with high expression in the testis, prostate, and colon. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. Defects in Sialate O-acetylesterase are a cause of autoimmune disease type 6 (AIS6). Individuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease.