Anti-S100A8 antibody

Anti-S100A8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to S100A8

ELISA, IHC-P

Human S100A8 / CAGA

CFAG antibody; CFAg antibody; MA387 antibody; 60B8Ag antibody; MIF antibody; 60B8AG antibody; L1AG antibody; NIF antibody; P8 antibody; p8 antibody; MIF antibody; NIF antibody; CAGA antibody; CFAG antibody; CGLA antibody; L1Ag antibody; MRP8 antibody; CP-10 antibody; MA387 antibody; 60B8AG antibody; B8Ag antibody; CFAg antibody; Caga antibody; MRP8 antibody; CP-10 antibody; 60B8Ag antibody; AI323541 antibody; AI323541 antibody; B8Ag antibody; Caga antibody; CAGA antibody; calgranulin A antibody; calgranulin-A antibody; CGLA antibody; CP-10 antibody; CP-10 antibody; MRP8 antibody; MRP8 antibody; MRP-8 antibody; MRP-8 antibody; p8 antibody; P8 antibody; S100a8 antibody; S100A8 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human S100A8 (rh S100A8; NP_002955.2; Leu 2-Glu 93). S100A8 specific IgG was purified by human S100A8 affinity chromatography

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.

• Passey RJ, et al. (1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56.
• Gebhardt C, et al. (2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72(11): 1622-31.
• Halayko AJ, et al. (2009) S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol. 87(10): 743-55.
• Ghavami S, et al. (2009) S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol. 625(1-3): 73-83.
• Ha YS, et al. (2010) mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer. Korean J Urol. 51(1): 15-20.