Anti-S100A3 antibody

Anti-S100A3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to S100A3

ELISA, WB

Mouse S100A3

S100a3 antibody; S100A3 antibody; S100E antibody; S100E antibody; S100E antibody; S100E antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse S100A3 (rh S100A3; NP_035440.1; Met1-Gln101). S100A3 specific IgG was purified by Mouse S100A3 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2 EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture.

• Kizawa, K. et al., 2008, J Biol Chem. 283 (8):5004-13.
• Kizawa, K. et al., 1998, J Invest Dermatol. 111 (5):879-86.
• Kizawa, K. et al., 2002, Biochem Biophys Res Commun. 299 (5):857-62.
• Fritz,G. et al., 2002, J Biol Chem. 277 (36):33092-8.