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Product Name
Anti-RbAp48 Rabbit antibody
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Description
RbAp48 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
NURF55; RBAP48; lin-53 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human RbAp48
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000-1/10000
IHC: 1/20
ICC/IF: 1/20
FC: 1/20
IP: 1/20
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Validations
Western blot detection of RbAp48 in Hela cell lysates using RbAp48 Rabbit pAb(1:1000 diluted).Predicted band size:48KDa.Observed band size:48KDa.
Immunocytochemistry of RbAp48(green) in Hela cells using RbAp48 Rabbit pAb at dilution 1/50, and DAPI(blue)
Immunohistochemistry of RbAp48 in paraffin-embedded Human lung cancer tissue using RbAp48 Rabbit pAb at dilution 1/20
Western blot detection of RbAp48 in Hela,CHO-K1,C6,Jurkat cell lysates using RbAp48 Rabbit pAb(1:500 diluted).Predicted band size:48kDa.Observed band size:48kDa.
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Background
Swiss-Prot Acc.Q09028.Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"