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  • Anti-Profilin 2 / PFN2 antibody

Anti-Profilin 2 / PFN2 antibody

Cat.#: 105757

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Product Information

  • Product Name
    Anti-Profilin 2 / PFN2 antibody
  • Documents
  • Description
    Rabbit monoclonal to Profilin 2 / PFN2
  • Tested applications
    WB
  • Species reactivity
    Human Profilin 2 / PFN2
  • Alternative names
    profilin 2 antibody; PFN2 antibody; D3S1319E antibody; PFL antibody; profilin II antibody; profilin 2 antibody; Pfn2 antibody; Pfn antibody; profilin II antibody; Pfn antibody; PFL antibody; D3S1319E antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human Profilin 2 / PFN2 (rh Profilin 2 / PFN2; AAH18049.1; Met1-Phe140).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-10 μg/ml

  • Validations

    Profilin 2 / PFN2 Antibody, Rabbit MAb, Western blot

    Profilin 2 / PFN2 Antibody, Rabbit MAb, Western blot

  • Background
    Profilin 2, also known as PFN2, is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. Profilin 2 binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. Profilin 2 is thought to regulate actin polymerization in response to extracellular signals. It inhibits the formation of IP3 and DG by binding to PIP2.
  • References
    • Da Silva. et al., 2003, J Cell Biol. 162 (7): 1267-79.
    • Honore B. et al., 1993, FEBS Lett. 330 (2): 151-5.
    • Joensuu T. et al., 1997, Genomics. 38 (3): 255-63.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"