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  • Anti-Phospho-Tau (Thr50) Rabbit antibody

Anti-Phospho-Tau (Thr50) Rabbit antibody

Cat.#: 166939

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Product Information

  • Product Name
    Anti-Phospho-Tau (Thr50) Rabbit antibody
  • Documents
  • Description
    Phospho-Tau (Thr50) Rabbit polyclonal antibody
  • Tested applications
    WB, ICC/IF, IP
  • Species reactivity
    Human
  • Alternative names
    TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic phosphopeptide corresponding to residues surrounding Thr50 of human Tau
  • Clonality
    Polyclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    ICC/IF: 1/50

    IP: 1/20

  • Validations

    Western blot detection of Tau (Phospho-Thr50) in Human Hippocampus lysates using Tau (Phospho-Thr50) Rabbit pAb(1:1000 diluted).Predicted band size:79KDa.Observed band size:50-80KDa.

    Western blot detection of Tau (Phospho-Thr50) in Human Hippocampus lysates using Tau (Phospho-Thr50) Rabbit pAb(1:1000 diluted).Predicted band size:79KDa.Observed band size:50-80KDa.

  • Background
    Swiss-Prot Acc.P10636.Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"