Anti-phospho-JNK1 (Thr183/Tyr185) Rabbit antibody

Anti-phospho-JNK1 (Thr183/Tyr185) Rabbit antibody

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• Material Safety Data Sheets (MSDS)

phospho-JNK1 (Thr183/Tyr185) Rabbit monoclonal antibody

WB, IP

Human

Rabbit IgG

Antigen: A synthetic phosphopeptide corresponding to residues surrounding Thr183/Tyr185 of human JNK1

Monoclonal

50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]